[HTML][HTML] Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β
X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been
shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury
has not yet been elucidated. The present study investigated the hepatoprotective effect of Iso
and its underlying mechanism. C57BL/6J mice were used to evaluate the hepatoprotective
effect of Iso in vivo and HepG2 cells were utilized to further decipher the mechanisms of Iso …
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been
shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury
has not yet been elucidated. The present study investigated the hepatoprotective effect of Iso
and its underlying mechanism. C57BL/6J mice were used to evaluate the hepatoprotective
effect of Iso in vivo and HepG2 cells were utilized to further decipher the mechanisms of Iso …
Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β
F Xiaoye, L Hongming, W Lidong, D Xuming… - Frontiers in … - frontiersin.org
< p> Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been
shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury
has not yet been elucidated. The present study investigated the hepatoprotective effect of Iso
and its underlying mechanism. C57BL/6J mice were used to evaluate the hepatoprotective
effect of Iso< italic> in vivo and HepG2 cells were utilized to further decipher the …
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been
shown to have antioxidant potential. However, the effect of Iso on APAP-induced liver injury
has not yet been elucidated. The present study investigated the hepatoprotective effect of Iso
and its underlying mechanism. C57BL/6J mice were used to evaluate the hepatoprotective
effect of Iso< italic> in vivo and HepG2 cells were utilized to further decipher the …
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